Our research focuses on the study of molecular cascades controlling limb development. We are most interested in the processes of limb identity, chondrogenesis and apoptosis, using chick as the main model. We are using microarray technology to search for new genes involved in limb identity and initiation. Our group also investigates the intracellular cascades that control cell fate during limb development, namely those involved in the triggering of programmed cell death versus chondrogenesis. For this project we are undertaking studies involving different kinase pathways, Smad mediated signaling and Wnt activity during limb outgrowth. We are also interested in exploring how limb shape is sculpted by apoptosis. For that purpose we are performing expression pattern analysis in different animal species such as chicken, duck and chamaeleon.