Recent Publications:

Kawakami Y, Rodriguez-Leon J, Belmonte JC. (2006) The role of TGFbetas and Sox9 during limb chondrogenesis. Curr Opin Cell Biol. 2006 Oct 13.

Kawakami Y, Esteban CR, Matsui T, Rodriguez-Leon J, Kato S, Belmonte JC. (2004) Sp8 and Sp9, two closely related buttonhead-like transcription factors, regulate Fgf8 expression and limb outgrowth in vertebrate embryos. Development. Oct;131(19):4763-74.

Zuzarte-Luís, V., Montero-Simón, J.A, Rodríguez-León, J., Merino, R., Rodriguez Rey, J.C. and Hurlé, J.M. (2004). A role for BMP5 during limb development acting through the synergic activation of Smad and MAPK pathways. Developmental Biology. 272, 39-52.

Raya, A., Kawakami, Y., Rodríguez-Esteban, C., Ibañes, M., Rasskin-Gutman, D., Rodríguez-León, J., Büscher, D., Feijó, J.A. and Izpisúa Belmonte, J.C. (2004). Notch activity acts as a sensor for extracellular calcium during vertebrate left-right determination. Nature, 427, 121-128.

Kawakami, Y., Rodríguez-León, J. *, Koth, C.M., Büscher, D., Itoh, T., Raya. A., Ng, J., Rodríguez Esteban, C., Takahashi, S., Henrique, D., SchwartZ, M., Asahara, H. and Izpisúa Belmonte, J.C. (2003). MKP3 Mediates the Cellular Response to FGF8 Signalling in the Vertebrate Limb. Nature Cell Biology 5, 513-519. * Co-authorship.

Chimal-Monroy, L., Rodriguez-Leon, J. *, Montero, J.A., Gañan, Y., Macias, D., Merino, R. and Hurle, J.M. (2003). Analysis Of The Molecular Cascade Responsible For Mesodermal Limb Chondrogenesis: Sox Genes And Bmp Signaling. Developmental Biology 257, 292-301. * Co-authorship.

Groppe, J., Greenwald, J., Wiater, E., Rodríguez-León, J., Economides, A.N., Kwiatkowski, W., Baban, K., Affolter, M., Vale, W.W., Izpisúa Belmonte, J.C. and Choe, S. (2003). Structural Basis Of Bmp Signaling Inhibition By Noggin, A Novel Twelve-Membered Cystine Knot Protein. The Jnl. of Bone and Joint Surgery 85-A, Suppl. 3:52-58.

Groppe, J., Greenwald, J., Wiater, E., Rodríguez-León, J., Economides, A.N., Kwiatkowski, W., Baban, K., Affolter, M., Vale, W.W., Izpisua Belmonte, J.C. and Choe, S. (2002). Structural Basis Of Bmp Signalling Inhibition By Noggin, A Novel Cystine Knot Protein. Nature. 420, 636-642.

Ng, J., Kawakami, Y., Büscher, D., Raya, A., Itoh, T., Koth, C., Rodríguez Esteban, C., Rodríguez-León, J. and Izpisúa Belmonte, J.C. (2002). The Limb Identity Gene Tbx5 Promotes Limb Initiation By Interacting With Wnt-2b And Fgf-10. Development. 129, 5161-5170

Trelles, R.D., Rodriguez Leon, J.*, Kawakami, Y., Simoes, S. and Izpisua Belmonte, J.C. (2002). Expression Of The Chick Endothelial Growth Factor D During Limb Development. Mechanisms of Development. 136, 239-242. * Co-authorship.

Tavares, A.T., Izpisúa Belmonte, J.C. and Rodríguez-León, J. (2001). Developmental Expression Of Chick Twist And Its Regulation During Limb Patterning. International Journal of Developmental Biology. 45, 707-713.

Montero, J.A., Gañan, Y., Macias, D., Rodriguez-León, J., Sanz-Ezquerro, J., Merino, R., Chimal-Monroy, J., Nieto, M.A. and Hurle, J.M. (2001). Role Of Fgfs In The Control Of Programmed Cell Death During Limb Development. Development 128, 2075-2084.

Merino, R., Rodríguez-León, J.*, Macías, D., Gañán, Y., Economides, A.N., y Hurlé, J.M.(1999). The Bmp Antagonist Gremlin Regulates Outgrowth, Chondrogenesis And Programmed Cell Death In The Developing Limb. Development. 126, 5515-5522. * Co-authorship

Rodríguez-León, J., Merino, R., Macias, D., Gañan, Y., Santesteban, E. y Hurle, J.M. (1999). Retinoic Acid Regulates Programmed Cell Death Through Bmp Signaling. Nature Cell Biology. 1, (2), 125-126.

Merino, R., Gañan, Y., Macias, D., Rodríguez-León, J. y Hurle, J.M. (1999). Bone Morphogenetic Proteins Regulate Interdigital Cell Death In The Avian Embryo. Review. Mechanisms of Cell Death, Vol. 887 Annals of New York Academy of Sciences. Pgs. 120-132.

Merino, R., Macias, D., Gañan, Y., Rodríguez-León, J., Eonomides, A.N., Rodriguez-Esteban, C., Izpisua-Belmonte, J.C. y Hurle, J.M. (1999).Control Of Digit Formation By Activin Signaling. Development. 126 (10), 2161-2170.

Macias, D., Gañan, Y., Rodríguez-León, J., Merino, R. y Hurle, J.M. (1999). Regulation By Members Of The Transforming Growth Factor Beta Superfamily Of The Digital And Interdigital Fates Of The Autopodial Limb Mesoderm. Review. Cell Tissue Research. 296 (1), 95-102.