Principal Investigators of Cells into Organs
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Prof. A.J. Durston | ||
| Hubrecht Laboratory / Netherlands Institute of Developmental Biology, Axial patterning | |||
| Durston investigates early pathways involved in constructing the posterior part of the vertebrate anterior-posterior (A-P) axis using Xenopus laevis as model system. | |||
| more information ¦ People ¦ Publications | |||
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Prof. M. Affolter | ||
| Biozentrum, University of Basel, Cell Biology | |||
| Affolter focusses on: Inductive cell interactions, Cell migration, DPP / BMP signaling, FGF signaling and Homeotic genes. | |||
| more information ¦ People ¦ Publications | |||
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Dr. A.G. Borycki | ||
| University of sheffield, Centre for developmental genetics | |||
| Borycki investigates the transcriptional regulation and function of the Gli genes during somite development of mouse and avian embryos. | |||
| more information | |||
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Prof. M.E. Buckingham | ||
| Institut Pasteur, Developmental Biology, Molecular Genetics of Development | |||
| Buckingham is interested in the regulatory genes which direct a cell into the myogenic programme of skeletal or cardiac muscle and in the cell lineages which contribute to these two striated muscle tissues. The model studied is the mouse, with genetic manipulation as an essential tool in our experimental approach. | |||
| more information ¦ People ¦ Publications | |||
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J. Charité, PhD | ||
| Erasmus University, Hox genes and hematopoiesis | |||
| Charité focusses on the regulation of Hox gene expression in the hematopoietic system, with the long-term aim of developing strategies to manipulate their expression in a therapeutic context. They further investigate the molecular mechanisms underlying the cellular "memory function". | |||
| more information | |||
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Prof. G. Cossu | ||
| Stem Cell Research Institute Dibit, Scientific Institute San Raffaele, Physiopathology of skeletal muscle development | |||
| Cossu focusses on the signals and mechanism that regulate the formation of skeletal muscle during embryonic development and, after birth, when the muscle tissue is damaged as a result of an injury or a primary myopathy. | |||
| more information | |||
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Dr. J. Deschamps | ||
| Hubrecht Laboratory of Developmental Biology, Mouse Hox genes | |||
| Deschamps studies the mechanism of action of Hox and Cdx genes in axial patterning of the mouse embryo, and the role of these genes in the hierarchy of genetic activities leading from the initially A-P polarised egg cylinder stage embryos to the correctly patterned foetus. | |||
| more information ¦ People ¦ Publications | |||
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Prof. D. Duboule | ||
| University of Geneva, Zoology and Animal Biology | |||
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Duboule investigates vertebrate patterning and evolution and, in particular, the role of the Hox gene family of transcription factors in these processes | |||
| more information ¦ People ¦ Publications | |||
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Prof.E. Dzierzak | ||
| Erasmus University, Hematopoietic stem cell development | |||
| Dzierzak aims to identify the molecules involved in the generation and expansion of hematopoietic stem cells by using a wide variety of cellular and molecular techniques. | |||
| more information | |||
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Prof. W.J. Gehring | ||
| Biozentrum, University of Basel, Cell Biology | |||
| Gehring focusses on: Developmental Genetics of Drosophila, Specification of the body plan, Homeobox, Master control genes and Eye Development and Evolution. | |||
| more information | |||
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Prof. F. Grosveld | ||
| Erasmus University, Cell Biology and Genetics | |||
| Grosveld tries to define the cellular and molecular mechanisms how chromatin activation and tissue specific transcription are achieved, using the b-globin gene cluster as a model system. | |||
| more information | |||
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Prof.Sir. J.B. Gurdon | ||
| The Wellcome Trust/Cancer Research UK Gurdon Institute, Fundamental mechanisms of cell fate determination | |||
| Gurdon is interested in nuclear reprogramming and cell fate determination by signal factors in amphibian development. They are also analysing the mechanisms by which secreted signal factors of the TGFbeta class can direct embryonic cells into divergent pathways of cell differentiation. | |||
| more information | |||
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Dr. C. Hartmann | ||
| Research Institute of Molecular Pathology, Formation and patterning of the vertebrate skeleton | |||
| Hartmann uses mouse and chick as model organisms to gain insight into how bone and cartilage formation are regulated during both, embryonic and postnatal development. In particular, we investigate the role of Wnt-signaling in skeletogenesis. | |||
| more information | |||
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Prof. P.W. Ingham | ||
| University of Sheffield, Centre for Developmental Genetics | |||
| Ingham's current research centres around the mechanisms and functions of Hedgehog signalling. Using the sophisticated genetics and in vivo imaging techniques available in Drosophila we are investigating the mechanisms of action of the Hh receptor protein, Patched and of Smoothened, the serpentine protein essential for transduction of the Hh signal. | |||
| more information | |||
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Dr. A. Jacinto | ||
| Gulbenkian Institute/ Institute of Molecular Medicine, Morphogenesis | |||
| Jacinto investigates the mechanisms that regulate the recruitment of macrophage-like blood cells to wound sites | |||
| more information ¦ People ¦ Publications | |||
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Prof. H. Jäckle | ||
| Max-Planck-Institute for Biophysical Chemistry, Molecular Developmental Biology | |||
| Jäckle focusses on: Pattern formation / Transcriptional control / Control of Translation, Cell-Cell interactions / Pathways / Cytoskeleton and Molecular Physiology | |||
| more information | |||
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Dr. H.C. Korswagen | ||
| Hubrecht Laboratory of Developmental Biology, Genetic dissection of Wnt signalling in C. elegans | |||
| Korswagen tries to understand how cells in the embryo translate and integrate the extracellular signals that control development. They are particularly intersetd in the Wnt familiy of secreted glycoporteins. | |||
| more information ¦ People ¦ Publications | |||
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J.F. Nicolas | ||
| Institut Pasteur, Developmental Biology, Molecular Biology of Development | |||
| Nicolas is interested in the cell behaviours and in their arrangement in spatio-temperal patterns during development. They use clonal analysis and in vivo imaging on several chordate models (zebrafish, chick, mouse and amphioxus) | |||
| more information | |||
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Dr. I. Palmeirim | ||
| School of Health Sciences, University of Minho, Vertebrate segmentation | |||
| The long-term aim of Palmeirim is to understand how time is controlled during embryonic development. | |||
| more information ¦ People ¦ Publications | |||
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Dr. J. Rodriguez Leon | ||
| Center of Regenerative Medicine in Barcelona | |||
| Rodriguez Leon focusses on the study of molecular cascades controlling limb development, using chick as main model. | |||
| more information ¦ People ¦ Publications | |||
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Dr. H. Roehl | ||
| University of Sheffield, Centre for Developmental Genetics | |||
| Roehl focusses on craniofacial development, using zebrafish as model. | |||
| more information | |||
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Prof. J.C. Smith | ||
| The Wellcome Trust/Cancer Research UK Gurdon Institute, Mesoderm formation in vertebrate embryos | |||
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Smith investigates the mechanisms by which the mesoderm of the vertebrate embryo is formed, using Xenopus and zebrafish embryos as model. Most of their work focusses on the Brachyury gene. | |||
| more information ¦ People ¦ Publications | |||
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Prof. C.D. Stern | ||
| University College London, Anatomy & Developmental Biology | |||
| Stern focusses on the processes that establish cell diversity and pattern in the early embryo. They are particularly interested in discovering mechanisms that represent general principles in development and therfore follow a multi-disciplinary approach. | |||
| more information ¦ People ¦ Publications | |||
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Dr. S. Thorsteinsdóttir | ||
| Gulbenkian Institute / Faculty of Sciences, University of Lisbon, Extracellular matrix | |||
| Thorsteinsdóttir focusses on the role of cell-extracellular matrix interactions during embryogenesis of mouse and chick using two different model systems; somitogenesis and skeletal muscle development. | |||
| more information ¦ People ¦ Publications | |||
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Prof. E.F. Wagner | ||
| Spanish National Cancer Research Centre | |||
| Wagner analysis gene function in normal and pathological conditions, using the mouse as model. Specifically, the functions of AP-1 in regulating cell proliferation, differentiation and cell death are investigated. | |||
| more information | |||
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Prof. L. Wolpert | ||
| University College London, Anatomy & Developmental Biology | |||
| more information | |||
